The dangers of trans fat have been known for quite some time now. Entire cities have banned this type of fat from being used in restaurants, while many more cities are on the precipice of enacting similar legislation. The stuff is bad for you, let's just say it. How bad? Well, trans fat has the dubious distinction of being the only fat that lowers good (HDL) cholesterol and raises bad (LDL) cholesterol, thereby greatly increasing one's risk of coronary heart disease.
Like I said, we've known for a while that trans fats are bad. Well, we thought we knew, anyway. Prior studies relied on self-reporting by test subjects when it came to determining how much or how little trans fat they consumed. As a result, the accuracy of the results were always somewhat in question, as people sometimes think they do something more or less than they actually do. But, a new study conducted at the Harvard School of Public Health has found a new method of measuring trans fat intake.
Because humans cannot synthesize trans fatty acids, they find their way into red blood cells. Utilizing their knowledge of this physiological fact, the researchers noted that the amount of trans fat in red blood cells is a biomarker of trans fat intake. The researchers then examined blood samples collected from 1989 and 1990 from almost thirty-three thousand participants from an unrelated study. The researches discovered that a higher level of trans fatty acids in red blood cells was associated with an increased risk of coronary heart disease, even when such variables as age, smoking, and other risk factors were taken into account. Specifically, the risk among women (all of the test participants were women) in the top quartile of trans fat levels was triple that of the lowest quartile.
This study will appear in the April 10, 2007 print issue of Circulation: Journal of the American Heart Association.