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Posts with tag serotonin

Chronic depression hardens arteries, contributes to heart attacks

A heavy heart is a hard heart. Chronic depression contributes greatly to the development of heart disease.

Depression produces sustained inflammation of the blood vessels, which can lead to hardening of the arteries, or atherosclerosis. This condition causes the heart to pump harder through narrowed vessels, and hardened pieces of the wall can break off forming a clot. Low-serotonin levels associated with chronic depression also come with elevated heart rate, increasing blood pressure. This phenomena also contributes to hardened arteries. In addition, low-serotonin results in thicker blood-- since the neurotransmitter is responsible for platelet activity that keeps the blood pumping smoothly. Sooner or later you've got a heart attack on your hands.

Other effects of depression on the heart include a constant production of cortisol, a stress induced hormone that serves as a key player in 'flight or fight' reaction. Constant high levels of cortisol contribute to high blood pressure, increased bad cholesterol and insulin levels, as well as an excess of abdominal fat.

Angry outbursts more than bad behavior

Suddenly he's honking the horn and screaming at another driver. Out of nowhere, she starts breaking dishes on the floor, enraged. Family members freeze, wait it out. Doctors have finally named a long-misunderstood condition-- intermittent explosive disorder. As many as 16 million Americans experience these uncontrollable temper outbursts. Recent studies have shown that people who are angrier in life are more prone to heart attacks and other cardiovascular diseases.

Intermittent explosive disorder is defined as multiple outbursts that are hugely out of proportion to the situation. For most sufferers, episodes begin in early adolescence and continue to cause problems later in life. The disorder involves a serotonin deficiency, the brain chemical that regulates mood and controls behavior. Many sufferers tend to use alcohol and drugs to self-medicate, which in turn aggravates the condition. Treatment is available, involving a combination of anti-depressants and anger management behavioral therapy.

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